(moxidectin) For Extended-Release Injectable Suspension for Dogs CAUTION Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Advocate flea treatment for dogs combines two monthly products – flea treatment plus heartworm medicine for dogs, into one. Can this drug be given with other drugs? 6 The animal should be standing for easy application. Overview of Moxidectin for Dogs and Cats. The ProHeart 6 product label includes vomiting, seizures, diarrhea, anaphylaxis, listlessness, weight loss, and elevated body temperature as potential side effects. They found moxidectin “ was generally safe and well tolerated ”. Moxidectin 5 gm. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. Moxidectin is also effective against ear mites, ... Side effects have not been reported for dogs using the topical product as directed. Filter Results Take this medication by mouth with a full glass of water (8 ounces or 240 milliliters) on an empty stomach at least 1 hour before a meal. Dogs and cats weighing less than 1 kg and ferrets weighing less than 0.8 kg should only be treated after special consideration by the veterinarian. These side-effects are possible, but do not always occur. Moxidectin was first used in 1989 as an injectable dewormer in cattle; later it was used in sheep and deer. Moxidectin is quickly absorbed through the skin into the subcutaneous fat and the bloodstream to prevent heartworm disease, treat and control internal parasites, treat sarcoptic mange in dogs and treat ear mites in cats. Symptoms of toxicity include dilated pupils, unsteadiness, mental dullness, drooling, vomiting, blindness, tremors, … Although no side effects have been confirmed in ferrets, similar side effects could occur rarely. They include fenbendazole, milbemycin, moxidectin, piperazine, and pyrantel. 2.5 mg/kg moxidectin for dogs; 1.0 mg/kg moxidectin for cats. Important Safety Information: Use PROHEART 6 in dogs 6 months of age or older and PROHEART 12 in dogs 12 months of age or older. Advocate is the combination of moxidectin and imidacloprid. It is also worth noting that ProHeart injections have been registered and available in Canada, the European Union (France, Greece, Italy, Portugal, Spain), Korea and Japan, and there have been no recalls or concerns over their safety. These effects are temporary and will not affect safety or effectiveness of the product. Overview of Advantage Multi™ for Canines and Felines Imidacloprid and Moxidectin is a combination of drugs commonly known as Advantage Multi™. Herding dogs such as Collies, Australian Shepherds, Shetland Sheepdogs, English Sheepdogs and related breeds, have a gene mutation that makes them especially sensitive to macrocyclic lactones, a class of parasiticides that includes ivermectin or moxidectin. Your vet will give your dog one to three doses at first, which will kill the adult worms. Moxidectin, also known as ProHeart®, is used primarily to prevent heartworm infection for dogs. PH 12 has a > 5× safety margin in both normal and ivermectin-sensitive dogs, has no effects on canine reproduction, and is well tolerated in heartworm-positive dogs. I understand that you would like to prevent fleas, ticks, heartworm and mosquitoes but I wouldn’t recommend using both products at the same time as they both use imidacloprid; using the Advantage … Imidacloprid is a … It has subsequently been used for the control of heartworm in dogs. Please note: The injectable form of Moxidectin was taken off the market due to potential side effects in dogs however is back on the market after passing extensive FDA safety testing. Black, tarry stools; bloating or swelling of the face, arms, hands, lower legs, or feet; bone or … Moxidectin side effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Our results indicate that moxidectin is effective and a good alternative for the treatment of demodicosis and scabies in dogs and psoroptic mange in rabbits. Do not administer to dogs that are sick, debilitated, underweight, have a history of weight loss, or to those previously found to be hypersensitive to the drug. Some of the side-effects may be rare but serious. Part the hair until the skin is visible. Properties: Moxidectin is a parasiticide active against a wide range of important internal and external parasites. Potential side effects will vary when using products with additional active ingredients. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. Along with its needed effects, a medicine may cause some unwanted effects. Advocate for Dogs, also known as Advantage Multi in some areas, is a leading treatment in veterinary medicine for canine heartworm. The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial swelling. This is not a comprehensive list. Lactation. If you have any questions, please contact your veterinarian. Overview of Moxidectin for Dogs and Cats Please note: The injectable form of Moxidectin was taken off the market due to potential side effects in dogs however is back on the market after passing extensive FDA safety testing. All seven rabbits treated for psoroptic mange were cured and did not show any side effect. Moxidectin Topical. Injectable moxidectin is not approved for use in heartworm infected dogs. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Transient swelling may occur at the site of injection. Safety of Ivermectin in Dogs . Report your Use » Learn more: Uses. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. The only treatment-related finding was non-adverse, granulomatous inflammation at the injection site. Advocate should not be used in kittens under 9 weeks of age or in puppies under 7 weeks of age. In many cases, the safety of Ivermectin is directly related to the dosage administered. Typically a dog owner would have to buy and administer two different products every month to accomplish the same thing as using Advocate. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. Precautions . Safety of an extended-release injectable moxidectin suspension formulation (ProHeart ® 12) in dogs Parasit Vectors. Advantage Multi ® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Zoetis knows moxidectin can be harmful to dogs. Moxidectin topical is applied to the skin and is commonly used to prevent heartworms and to treat topical and intestinal parasites. Remove any collar prior to application and replace when product is dry. Even after your dog is treated, they should get regular fecal exams. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. The moxidectin may be used as a direct prevention for heartworm and is also a treatment for microfilariae in dogs; imidacloprid is a mosquito repellent which will also prevent heartworm. Your dog will get follow-up doses to kill any new worms that weren’t fully developed when the first doses were given. Moxidectin, also known as ProHeart®, is used primarily to prevent heartworm infection for dogs. Studies of moxidectin show the side effects vary by animal and may be affected by the product's formulation, application method and dosage. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Demodicosis in dogs ; Moxidectin may also be used for purposes not listed here. 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